Multi-Scale Characterization of Human Tooth Enamel
Developmental defects of tooth enamel are a health problem of public concern. A combination of macro-, micro-, and nanoscale structural and chemical characterization of human enamel was used to study and compare enamel from healthy and diseased teeth. This work resulted from our collaboration with Dr. Sophia Houari (Université Paris Cité, Sorbonne Université, Paris, FR). Using the most advanced nanoscale imaging and analytical techniques, our contribution to this work showed that dental fluorosis (DF) is characterized by a loss of crystallinity mainly affecting the outer layer of enamel, and molar incisor hypomineralization (MIH) is associated with localized defects where crystalline material is embedded in an organic matrix. Only minor differences in the elemental composition of the mineral phase were found.
Publication
S. Houari, K. DeRocher, T. T. Thuy, T. Coradin, V. Srot, P. A. van Aken, H. Lecoq, T. Sauvage, E. Balan, J. Aufort, M. Calemme, N. Roubier, J. Bosco, K. Jedeon, A. Berdal, D. Joester, S. Babajko, Multi-scale characterization of Developmental Defects of Enamel and their clinical significance for diagnosis and treatment, Acta Biomaterialia 169, 155-167 (2023).
https://doi.org/10.1016/j.actbio.2023.08.011
Media appearance
ESTEEM3 – The main achievements in Electron Microscopy